Equilibrio hormonal y bienestar - Maca 30:1 Sinergia completa

Descripción

Why 30:1?

Maca 30:1 is a concentrated exract of Peruvian Maca root that has the power of 30 times of a simple extract.

With simple words, receiving 2081,4mg of Maca 30:1 Extract, equals to 62.442mg of a simple 1:1 extract.

You take 1 and it works for 30!

Synergy in action:

The main action of Maca 30:1 Extract, is being maximized by the rest of the ingrediets, which, not only multiply the effectiveness of Maca Extract, but also provide numerous of other benefits for hormonal and general health.

Ingredients as Magnesium bisglycinate, Ashwagandha, Wheat germ with spermidine and polyamine, L-Theanine, Microliposomal Zinc, Pantothenic acid, Astragin™ and vitamin B6, complete and maximize the effect of our formula, to give an unbeatable effect.

Maca 30:1 Fórmula Sinérgica Completa Banefits:

• Aumenta la libido en hombres y mujeres
• Aumenta la fertilidad en los hombres
• Ayuda a aliviar los síntomas de la menopausia
• Mejora el estado de ánimo
• Aumenta el rendimiento deportivo y la energía
• Mejora el aprendizaje y la memoria
• Reduce el tamaño de la próstata
• Favorece la propiocepción y el aprendizaje sensorial (cinestésico)
• Salud hormonal equilibrada
• Mejora del cerebro y la memoria
• Apoyo a la salud hepática
• Salud intestinal y apoyo al microbioma
• Apoyo inmunitario 
• Propiedades antienvejecimiento y protectoras de las células

What is inside Maca 30:1 Complete Synergy:

Nutrientes por dosis diaria recomendada:

*VNR Valor de referencia de nutrientes

Maca Benefits:

What Is Maca?

The maca plant, known scientifically as Lepidium meyenii, is sometimes referred to as Peruvian ginseng.

Aumenta la libido en hombres y mujeres

It May Increase Fertility in Men

It May Help Relieve Symptoms of Menopause

Maca Can Improve Your Mood

Several studies have shown that maca can enhance your mood.
It’s been associated with reduced anxiety and symptoms of depression, particularly in menopausal women
Maca contains plant compounds called flavonoids, which have been suggested to be at least partly responsible for these psychological benefits.

It May Boost Sports Performance and Energy

Maca root powder is a popular supplement among bodybuilders and athletes.

It May Improve Learning, Memory, proprioception and sensory (kinesthetic) learning

Maca may improve brain function.

It May Reduce Prostate Size

The prostate is a gland only found in men.

AstraGin^® es un nutracéutico para el intestino patentado por NuLiv Science, compuesto por ingredientes altamente purificados y fraccionados. Panax notoginsengy Astragalus membranaceus produced by a proprietary pharmaceutical extraction and processing technology.

AstraGin^® ha demostrado en 16 in-vitro y 8 in-vivo estudios publicados en el Journal of Agricultural and Food Chemistry, Molecular Nutrition & Food Research y Scientific Reports:

• Aumentan la absorción de péptidos, aminoácidos, ácidos grasos, vitaminas y fitonutrientes mediante la regulación del ARNm específico de la absorción y de los transportadores, como SGLT1, CAT1 y GLUT4.
• Repara las paredes intestinales ulceradas y dañadas y reduce la inflamación de la submucosa intestinal.* AstraGin^® se demostró en una tinción de hematoxilina-eosina y en un ensayo de MPO que reducía la ulceración y las superficies poco claras de las células epiteliales intestinales y el edema submucoso en ratas con colitis inducida por TNBS.
• Puede ayudar a mantener una población de microbiota sana reparando las superficies de las células epiteliales intestinales ulceradas y dañadas para que la microbiota pueda poblarlas*.
• Puede ayudar a reforzar las funciones inmunitarias reparando las células epiteliales ulceradas y reduciendo la inflamación en la lámina propia de la mucosa intestinal que alberga el tejido linfoide asociado al intestino (GALT1), células T, células plasmáticas, mastocitos, células dendríticas y macrófagos.

ZincNova

Microliposomal Zinc

Each serving of Maca 30:1 Complete Synergy , provides the 250% del Zinc que un adulto necesita durante su día, el máximo permitido por las autoridades sanitarias de la UE para el uso de suplementos.

ZincNova is a patented zinc form, which enhances and maximizes the absorption of zinc, due to the unique micro-liposomal absorption technology

Beneficios del zinc:

• El zinc contribuye al metabolismo ácido-base normal.
• El zinc contribuye al metabolismo normal de los hidratos de carbono.
• El zinc contribuye a una función cognitiva normal.
• El zinc contribuye a la síntesis normal del ADN.
• El zinc contribuye a la fertilidad y la reproducción normales.
• El zinc contribuye al metabolismo normal de los macronutrientes.
• El zinc contribuye al metabolismo normal de los ácidos grasos.
• El zinc contribuye al metabolismo normal de la vitamina A.
• El zinc contribuye a la síntesis normal de proteínas.
• El zinc contribuye al mantenimiento de unos huesos normales.
• El zinc contribuye al mantenimiento de un cabello normal.
• El zinc contribuye al mantenimiento de una piel normal.
• El zinc contribuye a mantener niveles normales de testosterona en la sangre.
• El zinc contribuye al mantenimiento de una visión normal.
• El zinc contribuye al funcionamiento normal del sistema inmunitario.
• El zinc contribuye a la protección de las células frente al estrés oxidativo.
• El zinc interviene en el proceso de división celular.

Zinc microencapsulado liposomal Zinc Zincnova™.

El zinc es uno de los oligoelementos más importantes en la nutrición humana. La carencia de zinc puede deberse a una ingesta inadecuada del mineral o a problemas de absorción, especialmente en personas con trastornos grastrointestinales.

ZINCNOVA™ es una forma no reactiva de óxido de zinc que se ha microencapsulado en un soporte graso de calidad alimentaria para evitar la absorción de humedad y retrasar las interacciones indeseables con otros componentes de las fórmulas alimentarias, preservando así su biodisponibilidad.

Funcionamiento normal del sistema inmunitario

Mantenimiento de huesos normales

Función cognitiva normal

Visión normal

L-Theanine

L-theanine is a compound that may support thinking, sleep, and relaxation and help with weight loss, blood pressure, and more.

L-theanine helps to lower levels of the stress hormone corticosterone and avoid interference with memory and learning.

Research suggests that L-theanine might provide a range of health benefits, which may include improved mental focus and better sleep quality. It occurs naturally in green and black tea, and is available in supplements.

Wheat Germ Extract providing 5% polyamine and 2% spermidine

Spermidine – The “fountain of youth” for your cells

What is spermidine?

This micronutrient belongs chemically to the polyamines. Spermidine is considered an effective activator of so-called autophagy. This is a recycling process within cells that leads to old cells renewing themselves and thus their activity can be restored. Recent studies support this notion and show that increased intake of this polyamine via a spermidine-rich diet reduces all-cause mortality associated with cardiovascular disease.

Where does spermidine come from?

Besides the body’s own production of spermidine, spermidine-rich foods and the gut microbiome are considered the most important sources. Polyamines like spermidine can be found in all kinds of food in a wide range of concentrations. A well-known plant source is wheat germ.

Currently, there are no official recommendations for the daily intake of spermidine, but clinical studies suggest that 1-6 mg per day is an optimal supplement. With increasing age, the body produces less and less spermidine, which is why it makes sense to take it as a food supplement.

How does spermidine benefit the body? Is spermidine anti-aging?

Spermidine taken in with food or food supplements is quickly absorbed in the intestine, so that the majority of the polyamines have already disappeared from the inside of the intestine shortly after a meal. The molecular mechanism, i.e. the exact way in which externally supplied polyamines are absorbed from the intestine into the blood, has not yet been definitively clarified. It is assumed that they enter the body by passive diffusion from the first section of the small intestine, the duodenum.

Alternative approaches assume that polyamines are taken up by various epithelial cells of the intestinal mucosa through a strictly regulated active transport process or that the uptake takes place through a so-called endocytosis – i.e. by invagination of the cell membrane region to which the spermidine has attached. These approaches suggest that cell-specific mechanisms are involved in the uptake of spermidine into the body, which still need to be described in more detail.

Gut bacteria are important spermidine producers

What’s the connection between your gut health and spermidine? Spermidine, which is produced by intestinal bacteria, is also absorbed into the body at the same site. Cellular mechanisms of the microbiome regulate the production of the polyamine. Spermidine produced from intestinal bacteria, which triggers autophagy, was able to reduce the risk of cardiovascular disease in mice in a series of experiments.

These beneficial bacteria can increase the production of putrescine, a spermidine precursor, in the gut. Also, a study showed that people who ate yoghurt with polyamine-producing microbes showed an improvement in their endothelial function (note: the endothelium is the cell layer on the inner surface of blood and lymph vessels). The authors conclude that eating polyamine-producing bacteria reduces the risk of atherosclerosis.

Article below from iherb.com

Spermidine And Longevity Benefits

Cellular rejuvenation, longevity, and anti-aging effects are the primary reason spermidine has recently gained the spotlight in recent years. Spermidine supplements are becoming more popular, and there is an ever-increasing demand for this compound, thanks to our desire for improved health span and lifespan. 

Interestingly, scientists have known about polyamines and their role in cellular metabolism for a long time. However, they only recently learned about spermidine levels diminishing as we age — opening up a new frontier of science for enhancing longevity and improving health.

Many animal and human studies suggest that spermidine plays a significant role in delaying aging and age-related diseases. For example, research published in the American Journal Of Clinical Nutrition shows that a diet rich in spermidine significantly improves longevity and reduces the death rate or mortality. 

However, the exact mechanism of action of spermidine remains to be understood, with most research so far pointing to the process of 

autophagy. For example, the authors of a 2018 research paper note that spermidine extends lifespan by promoting autophagy and might be as powerful as rapamycin — an FDA-approved immunosuppressant with potent autophagy stimulatory properties. However, before we delve into how spermidine promotes autophagy, let’s first understand the role of autophagy in longevity

Spermidine and Autophagy

Autophagy (Latin for self-eating) is a process that occurs  when the body cleanses damaged cells by “eating them.” Those who practice intermittent fasting may be familiar with this process, which is believed to begin after 16 hours of fasting. Cells use autophagy to degrade their old and damaged parts and reuse them for either cellular repair or generate new cells. In a sense, autophagy is the body recycling old and damaged components and re-utilizing them.  

However, research suggests that the rate of autophagy decreases with age, leading to an accumulation of damaged and aged cells. The failure of this recycling process, in turn, has been linked to many age-related conditions, such as neurodegeneration, infections, and numerous autoimmune diseases. In addition, while defects in the autophagy mechanism speed up aging, evidence suggests that the promotion of this process can improve health and promote longevity. 

How Spermidine Promotes Autophagy

Over the last decade, scientists began to test the hypothesis that lifestyle, diet, and certain supplements may help induce autophagy. These include calorie restriction, exercise, intermittent fasting, a ketogenic diet, medications (rapamycin), green tea, and natural supplements like resveratrol, turmeric, NMN, and spermidine.  

As a result, plenty of research now suggests that although spermidine supports longevity in many different ways, the primary mechanism involved is autophagy. 

For example, a 2009 study showed that spermidine administration markedly extended the lifespan of yeast, flies, worms, and human immune cells. The researchers found that spermidine inhibited certain enzymes known as acetyltransferases. These enzymes are involved in DNA health. As a result, the gene expression in autophagy increased, reducing cell death and enhancing longevity.

Interestingly, a 2010 study showed that while spermidine enhances autophagy in many species, including yeast, worms, flies, and humans, the inactivation of genes for autophagy abolishes the life-enhancing benefits of spermidine in these species. Similarly, the authors of a 2011 study note that spermidine and resveratrol, while inducing autophagy through different pathways, both converge at modifying and inhibiting the same enzymes, i.e., acetyltransferases. Thus, the two supplements not only support longevity but could complement each other. 

In addition, a 2014 study found that the primary enzyme that inhibits autophagy is EP300, and supplementing with spermidine turns off the activity of this enzyme — leading to enhanced longevity. Thus, plenty of research has established a strong relationship between spermidine and autophagy. However, as spermidine becomes more and more mainstream, scientists are now exploring its role in specific age-related health conditions like brain and heart disease.  

Spermidine and Cardiovascular Well-being

Improving cardiovascular health is the extension of the same phenomenon. For example, a 2016 study found that spermidine shows cardioprotective effects in mice by promoting autophagy and preserving the heart’s function. Cardiovascular health problems have become the leading cause of death worldwide, with ischemic heart disease alone accounting for 16 percent of deaths, according to World Health Organization. As a result, finding ways to manage this plethora of health conditions is the need of the hour. And spermidine supplementation might hold the potential as an alternative therapy.

The authors of a 2017 study on lab mice found that spermidine and spermine upregulate or downregulate many proteins and metabolites involved in immune responses, blood coagulation, lipid metabolism, and glutathione (an antioxidant) metabolism pathways. Likewise, a 2019 study found that spermidine supplementation enhances heart cell viability, decreases cell death, reduces infarction size, and improves heart function in mice with a recent heart attack.

After seeing the cardioprotective benefits of spermidine, researchers began conducting human trials. As a result, in a 2022 study, a team of researchers recruited 377 patients with acute myocardial infarction (AMI) and measured their serum spermidine and oxidative stress (free radical damage due to lack of blood flow) indexes. The researchers found that people with higher spermidine levels in their blood had a better survival probability than those with lower spermidine levels, leading researchers to conclude that spermidine could be a potential biomarker for predicting heart attack outcomes. However, more research is needed to make objective claims.

Spermidine’s Brain and Cognitive Benefits 

Besides longevity and heart protection, spermidine also greatly benefits the brain and cognitive function and protects against common age-related brain disorders like Alzheimer’s and Parkinson’s disease. A large body of evidence suggests that spermidine can prove very helpful for an aging brain, especially when the world population is aging very speedily and dementia is becoming more common. For example, a 2020 lab study indicates that the effect of spermidine and spermine on anti-aging is related to improving autophagy and mitochondrial function.

Likewise, a 2020 study shows spermidine inhibits memory loss in worms with Alzheimer’s disease and improves behavioral performance, e.g., locomotor capacity, in worms with Parkinson’s disease by mitophagy (a type of autophagy). Additionally, spermidine delays accelerated/premature aging by improving DNA repair. Furthermore, a 2021 research paper has shown a link between higher dietary spermidine intake and reduced risk for cognitive impairment in humans. The researchers found that maintaining mitochondrial and autophagic function by spermidine feeding is essential for enhanced cognition.

However, more human-based clinical trials are needed to establish a robust causal relationship between spermidine and improved brain health.

Spermidine’s Anti-Inflammatory and Immune-Boosting Properties

Inflammation is a natural defense mechanism in the body against foreign invaders such as bacteria, viruses, fungi, parasites, and other triggers. However, sometimes, inflammation gets out of hand, leading to significant morbidity and becoming a menace. However, the good news is spermidine may also hold a potential role in inflammatory disorders such as rheumatoid arthritis and inflammatory bowel disease. For example, a 2012 study published in the Journal of Biomedical Science indicates that spermidine shows anti-inflammatory properties by blocking causes of inflammation (such as the nuclear factor kappa B (NF-κB) and MAP kinases (MAPKs) signaling pathways). 

Furthermore, a 2017 lab model shows that spermidine has antioxidant properties and protects against oxidative stress by reducing the intracellular accumulation of reactive oxygen species. Reactive oxygen species are free radicals that damage the body in chronic inflammation, such as in rheumatoid arthritis, ischemic heart disease, and many other lung, kidney, and liver pathologies. Likewise, research published in the Journal of Inflammation Research showed that spermidine suppressed the levels of the pro-inflammatory cytokines IL-6 and IL-1β and increased the levels of the anti-inflammatory factor IL-10 in the serum.

Additional Health Benefits

As researchers shed more and more light on spermidine, they find great potential for this compound in many disorders. Recent evidence has found that spermidine might prove helpful in several different types of illnesses, from tumors to muscular pathologies and skin diseases to gut problems. For example, a 2023 study indicates that spermidine interferes explicitly with the tumor cell cycle, inhibiting tumor cell proliferation and suppressing tumor growth. 

Furthermore, recent research also shows a connection between spermidine and youthful skin and improved gut health.

Información sobre el producto:

• Servir: 1 scoop of 3g
• Porciones por envase: 42
• Powder weight in each tube: 126g
• Sabor: Natural Herb Flavour with sweeteners and Lemon