Hormonal Balance & Well-Being – Maca 30:1 Complete synergy

Description

Why 30:1?

Maca 30:1 is a concentrated exract of Peruvian Maca root that has the power of 30 times of a simple extract.

With simple words, receiving 2081,4mg of Maca 30:1 Extract, equals to 62.442mg of a simple 1:1 extract.

You take 1 and it works for 30!

Synergy in action:

The main action of Maca 30:1 Extract, is being maximized by the rest of the ingrediets, which, not only multiply the effectiveness of Maca Extract, but also provide numerous of other benefits for hormonal and general health.

Ingredients as Magnesium bisglycinate, Ashwagandha, Wheat germ with spermidine and polyamine, L-Theanine, Microliposomal Zinc, Pantothenic acid, Astragin™ and vitamin B6, complete and maximize the effect of our formula, to give an unbeatable effect.

Maca 30:1 Complete Synergy Formula Banefits:

• It Increases Libido in Men and Women
• It Increases Fertility in Men
• It Helps Relieve Symptoms of Menopause
• Improves Your Mood
• It Boosts Sports Performance and Energy
• It Improves Learning and Memory
• It Reduces Prostate Size
• It helps proprioception and sensory (kinesthetic) learning
• Balanced Hormonal Health
• Brain & Memory Improvement
• Liver Health Support
• Gut Health & Microbiome Support
• Immune Support 
• Anti-aging and Cell-Protecting Properties

What is inside Maca 30:1 Complete Synergy:

Nutrients per recommended daily dose:

*NRV Nutrient Reference Value

Maca Benefits:

What Is Maca?

The maca plant, known scientifically as Lepidium meyenii, is sometimes referred to as Peruvian ginseng.

It Increases Libido in Men and Women

It May Increase Fertility in Men

It May Help Relieve Symptoms of Menopause

Maca Can Improve Your Mood

Several studies have shown that maca can enhance your mood.
It’s been associated with reduced anxiety and symptoms of depression, particularly in menopausal women
Maca contains plant compounds called flavonoids, which have been suggested to be at least partly responsible for these psychological benefits.

It May Boost Sports Performance and Energy

Maca root powder is a popular supplement among bodybuilders and athletes.

It May Improve Learning, Memory, proprioception and sensory (kinesthetic) learning

Maca may improve brain function.

It May Reduce Prostate Size

The prostate is a gland only found in men.

AstraGin^® is NuLiv Science’s proprietary gut nutraceutical composed of highly purified and fractionated Panax notoginsengand Astragalus membranaceus produced by a proprietary pharmaceutical extraction and processing technology.

AstraGin^® has shown in 16 in-vitro and 8 in-vivo studies that are published in the Journal of Agricultural and Food Chemistry, Molecular Nutrition & Food Research and Scientific Reports to:

• Increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up-regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4.*
• Repair ulcerated and damaged intestinal walls and reduce intestinal submucosa inflammation.* AstraGin^® was shown in a hematoxylin-eosin stain and an MPO assay to reduce ulceration and unclear surfaces of intestinal epithelial cells and sub-mucosal edema in TNBS-induced colitis rats.
• May help maintain a healthy microbiota population by mending ulcerated and damaged intestinal epithelial cell surfaces for the microbiota to populate.*
• May help support stronger immune functions by mending ulcerated epithelial cells and reducing the inflammation in intestinal mucosal lamina propria that hosts the gut-associated lymphoid tissue (GALT1), T cells, plasma cells, mast cells, dendritic cells, and macrophages.

ZincNova™

Microliposomal Zinc

Each serving of Maca 30:1 Complete Synergy , provides the 250% of the Zinc that an adult needs during his day, the maximum allowed by EU health authorities for supplement use.

ZincNova™ is a patented zinc form, which enhances and maximizes the absorption of zinc, due to the unique micro-liposomal absorption technology

Zinc Benefits:

• Zinc contributes to normal acid-base metabolism.
• Zinc contributes to normal carbohydrate metabolism.
• Zinc contributes to normal cognitive function.
• Zinc contributes to normal DNA synthesis.
• Zinc contributes to normal fertility and reproduction.
• Zinc contributes to normal macronutrient metabolism.
• Zinc contributes to normal metabolism of fatty acids.
• Zinc contributes to normal metabolism of vitamin A.
• Zinc contributes to normal protein synthesis.
• Zinc contributes to the maintenance of normal bones.
• Zinc contributes to the maintenance of normal hair.
• Zinc contributes to the maintenance of normal skin.
• Zinc contributes to the maintenance of normal testosterone levels in the blood.
• Zinc contributes to the maintenance of normal vision.
• Zinc contributes to the normal function of the immune system.
• Zinc contributes to the protection of cells from oxidative stress.
• Zinc has a role in the process of cell division.

Zincnova™ Microencapsulated Liposomal Zinc

Zinc is one of the most important trace minerals in human nutrition. Zinc deficiency can be due to inadequate intake of the mineral or to problems with absorption especially in people with grastrointestinal disorders.

ZINCNOVA™ is a non-reactive form of zinc oxide that has been microencapsulated in a food grade fat carrier to prevent moisture uptake and to delay undesirable interactions with other components of food formulations, thus preserving its bioavailability.

Normal function of the inmune system

Maintenance of normal bones

Normal cognitive function

Normal vision

L-Theanine

L-theanine is a compound that may support thinking, sleep, and relaxation and help with weight loss, blood pressure, and more.

L-theanine helps to lower levels of the stress hormone corticosterone and avoid interference with memory and learning.

Research suggests that L-theanine might provide a range of health benefits, which may include improved mental focus and better sleep quality. It occurs naturally in green and black tea, and is available in supplements.

Wheat Germ Extract providing 5% polyamine and 2% spermidine

Spermidine – The “fountain of youth” for your cells

What is spermidine?

This micronutrient belongs chemically to the polyamines. Spermidine is considered an effective activator of so-called autophagy. This is a recycling process within cells that leads to old cells renewing themselves and thus their activity can be restored. Recent studies support this notion and show that increased intake of this polyamine via a spermidine-rich diet reduces all-cause mortality associated with cardiovascular disease.

Where does spermidine come from?

Besides the body’s own production of spermidine, spermidine-rich foods and the gut microbiome are considered the most important sources. Polyamines like spermidine can be found in all kinds of food in a wide range of concentrations. A well-known plant source is wheat germ.

Currently, there are no official recommendations for the daily intake of spermidine, but clinical studies suggest that 1-6 mg per day is an optimal supplement. With increasing age, the body produces less and less spermidine, which is why it makes sense to take it as a food supplement.

How does spermidine benefit the body? Is spermidine anti-aging?

Spermidine taken in with food or food supplements is quickly absorbed in the intestine, so that the majority of the polyamines have already disappeared from the inside of the intestine shortly after a meal. The molecular mechanism, i.e. the exact way in which externally supplied polyamines are absorbed from the intestine into the blood, has not yet been definitively clarified. It is assumed that they enter the body by passive diffusion from the first section of the small intestine, the duodenum.

Alternative approaches assume that polyamines are taken up by various epithelial cells of the intestinal mucosa through a strictly regulated active transport process or that the uptake takes place through a so-called endocytosis – i.e. by invagination of the cell membrane region to which the spermidine has attached. These approaches suggest that cell-specific mechanisms are involved in the uptake of spermidine into the body, which still need to be described in more detail.

Gut bacteria are important spermidine producers

What’s the connection between your gut health and spermidine? Spermidine, which is produced by intestinal bacteria, is also absorbed into the body at the same site. Cellular mechanisms of the microbiome regulate the production of the polyamine. Spermidine produced from intestinal bacteria, which triggers autophagy, was able to reduce the risk of cardiovascular disease in mice in a series of experiments.

These beneficial bacteria can increase the production of putrescine, a spermidine precursor, in the gut. Also, a study showed that people who ate yoghurt with polyamine-producing microbes showed an improvement in their endothelial function (note: the endothelium is the cell layer on the inner surface of blood and lymph vessels). The authors conclude that eating polyamine-producing bacteria reduces the risk of atherosclerosis.

Article below from iherb.com

Spermidine And Longevity Benefits

Cellular rejuvenation, longevity, and anti-aging effects are the primary reason spermidine has recently gained the spotlight in recent years. Spermidine supplements are becoming more popular, and there is an ever-increasing demand for this compound, thanks to our desire for improved health span and lifespan. 

Interestingly, scientists have known about polyamines and their role in cellular metabolism for a long time. However, they only recently learned about spermidine levels diminishing as we age — opening up a new frontier of science for enhancing longevity and improving health.

Many animal and human studies suggest that spermidine plays a significant role in delaying aging and age-related diseases. For example, research published in the American Journal Of Clinical Nutrition shows that a diet rich in spermidine significantly improves longevity and reduces the death rate or mortality. 

However, the exact mechanism of action of spermidine remains to be understood, with most research so far pointing to the process of 

autophagy. For example, the authors of a 2018 research paper note that spermidine extends lifespan by promoting autophagy and might be as powerful as rapamycin — an FDA-approved immunosuppressant with potent autophagy stimulatory properties. However, before we delve into how spermidine promotes autophagy, let’s first understand the role of autophagy in longevity

Spermidine and Autophagy

Autophagy (Latin for self-eating) is a process that occurs  when the body cleanses damaged cells by “eating them.” Those who practice intermittent fasting may be familiar with this process, which is believed to begin after 16 hours of fasting. Cells use autophagy to degrade their old and damaged parts and reuse them for either cellular repair or generate new cells. In a sense, autophagy is the body recycling old and damaged components and re-utilizing them.  

However, research suggests that the rate of autophagy decreases with age, leading to an accumulation of damaged and aged cells. The failure of this recycling process, in turn, has been linked to many age-related conditions, such as neurodegeneration, infections, and numerous autoimmune diseases. In addition, while defects in the autophagy mechanism speed up aging, evidence suggests that the promotion of this process can improve health and promote longevity. 

How Spermidine Promotes Autophagy

Over the last decade, scientists began to test the hypothesis that lifestyle, diet, and certain supplements may help induce autophagy. These include calorie restriction, exercise, intermittent fasting, a ketogenic diet, medications (rapamycin), green tea, and natural supplements like resveratrol, turmeric, NMN, and spermidine.  

As a result, plenty of research now suggests that although spermidine supports longevity in many different ways, the primary mechanism involved is autophagy. 

For example, a 2009 study showed that spermidine administration markedly extended the lifespan of yeast, flies, worms, and human immune cells. The researchers found that spermidine inhibited certain enzymes known as acetyltransferases. These enzymes are involved in DNA health. As a result, the gene expression in autophagy increased, reducing cell death and enhancing longevity.

Interestingly, a 2010 study showed that while spermidine enhances autophagy in many species, including yeast, worms, flies, and humans, the inactivation of genes for autophagy abolishes the life-enhancing benefits of spermidine in these species. Similarly, the authors of a 2011 study note that spermidine and resveratrol, while inducing autophagy through different pathways, both converge at modifying and inhibiting the same enzymes, i.e., acetyltransferases. Thus, the two supplements not only support longevity but could complement each other. 

In addition, a 2014 study found that the primary enzyme that inhibits autophagy is EP300, and supplementing with spermidine turns off the activity of this enzyme — leading to enhanced longevity. Thus, plenty of research has established a strong relationship between spermidine and autophagy. However, as spermidine becomes more and more mainstream, scientists are now exploring its role in specific age-related health conditions like brain and heart disease.  

Spermidine and Cardiovascular Well-being

Improving cardiovascular health is the extension of the same phenomenon. For example, a 2016 study found that spermidine shows cardioprotective effects in mice by promoting autophagy and preserving the heart’s function. Cardiovascular health problems have become the leading cause of death worldwide, with ischemic heart disease alone accounting for 16 percent of deaths, according to World Health Organization. As a result, finding ways to manage this plethora of health conditions is the need of the hour. And spermidine supplementation might hold the potential as an alternative therapy.

The authors of a 2017 study on lab mice found that spermidine and spermine upregulate or downregulate many proteins and metabolites involved in immune responses, blood coagulation, lipid metabolism, and glutathione (an antioxidant) metabolism pathways. Likewise, a 2019 study found that spermidine supplementation enhances heart cell viability, decreases cell death, reduces infarction size, and improves heart function in mice with a recent heart attack.

After seeing the cardioprotective benefits of spermidine, researchers began conducting human trials. As a result, in a 2022 study, a team of researchers recruited 377 patients with acute myocardial infarction (AMI) and measured their serum spermidine and oxidative stress (free radical damage due to lack of blood flow) indexes. The researchers found that people with higher spermidine levels in their blood had a better survival probability than those with lower spermidine levels, leading researchers to conclude that spermidine could be a potential biomarker for predicting heart attack outcomes. However, more research is needed to make objective claims.

Spermidine’s Brain and Cognitive Benefits 

Besides longevity and heart protection, spermidine also greatly benefits the brain and cognitive function and protects against common age-related brain disorders like Alzheimer’s and Parkinson’s disease. A large body of evidence suggests that spermidine can prove very helpful for an aging brain, especially when the world population is aging very speedily and dementia is becoming more common. For example, a 2020 lab study indicates that the effect of spermidine and spermine on anti-aging is related to improving autophagy and mitochondrial function.

Likewise, a 2020 study shows spermidine inhibits memory loss in worms with Alzheimer’s disease and improves behavioral performance, e.g., locomotor capacity, in worms with Parkinson’s disease by mitophagy (a type of autophagy). Additionally, spermidine delays accelerated/premature aging by improving DNA repair. Furthermore, a 2021 research paper has shown a link between higher dietary spermidine intake and reduced risk for cognitive impairment in humans. The researchers found that maintaining mitochondrial and autophagic function by spermidine feeding is essential for enhanced cognition.

However, more human-based clinical trials are needed to establish a robust causal relationship between spermidine and improved brain health.

Spermidine’s Anti-Inflammatory and Immune-Boosting Properties

Inflammation is a natural defense mechanism in the body against foreign invaders such as bacteria, viruses, fungi, parasites, and other triggers. However, sometimes, inflammation gets out of hand, leading to significant morbidity and becoming a menace. However, the good news is spermidine may also hold a potential role in inflammatory disorders such as rheumatoid arthritis and inflammatory bowel disease. For example, a 2012 study published in the Journal of Biomedical Science indicates that spermidine shows anti-inflammatory properties by blocking causes of inflammation (such as the nuclear factor kappa B (NF-κB) and MAP kinases (MAPKs) signaling pathways). 

Furthermore, a 2017 lab model shows that spermidine has antioxidant properties and protects against oxidative stress by reducing the intracellular accumulation of reactive oxygen species. Reactive oxygen species are free radicals that damage the body in chronic inflammation, such as in rheumatoid arthritis, ischemic heart disease, and many other lung, kidney, and liver pathologies. Likewise, research published in the Journal of Inflammation Research showed that spermidine suppressed the levels of the pro-inflammatory cytokines IL-6 and IL-1β and increased the levels of the anti-inflammatory factor IL-10 in the serum.

Additional Health Benefits

As researchers shed more and more light on spermidine, they find great potential for this compound in many disorders. Recent evidence has found that spermidine might prove helpful in several different types of illnesses, from tumors to muscular pathologies and skin diseases to gut problems. For example, a 2023 study indicates that spermidine interferes explicitly with the tumor cell cycle, inhibiting tumor cell proliferation and suppressing tumor growth. 

Furthermore, recent research also shows a connection between spermidine and youthful skin and improved gut health.

Product Information:

• Serving: 1 scoop of 3g
• Servings per container: 42
• Powder weight in each tube: 126g
• Flavour: Natural Herb Flavour with sweeteners and Lemon